– English Lyrics

Lyrics & Translation

[English]

I am a scientist and a drug developer. I

develop gene therapy designed to fix a

single error, a typo in the human

generic code that could cause life

written diseases such as blindness.

totally

lost of a human vision.

But I truly understand the purpose

through a student as a rare disease

degenerated her retina. The tax in her

books dissolved.

She losed the ability to navigate campus

and had to leave from university. Her

word photo of potential

began to really close in.

Medicine calls her condition rare

because it affect fewer than one in

2,000 people.

But here's the truth that reshaped my

life's work. There are over 7,000 such

rare diseases.

At every story together, you will find

a patient population of 350 million

people worldwide.

That's a population of United States,

Canada, and Australia combined.

Now, one in 15 people affected globally.

My folks on one gene, one disease

is not a niche pursuit. It is one vital

piece of 350 million people puzzle.

We medicalized isolation by calling them

rare.

Solving this is how we build a future

that everyone counts.

Those

puzzles have a devastating human cost

defined by two crew gaps.

The first gap is a diagnostic gap. For

progressive diseases,

times equals loss function. Yet

not everyone can receive a genetic test

that tells you what's wrong on the DNA

before it become actionable.

Even you can find the answer

but often after the time or the best

window for intervention has closed.

The second is a treatment gap.

After that long search, a harder truth

emerges.

Only a few tiny percentage of the rare

disease have a proved therapy. For the

vast majority, the diagnosis is an

answer but not a cure.

Patients exchange

the wildness of the unknown for the

agony of the untreatable.

It takes 10 to 15 years to develop one

medicine from discovery to market by

following a historical approach.

The most heartbreaking result

disease causes about 30%

of the deaths in UNATO intensive care

ICU.

Those are babies whose puzzle we cannot

solve.

is either science or speed in time.

This is not a just a challenging. It's a

human emergency hiding in plain sight.

So how do we solve the puzzle?

My field gene therapy aims for one-time

treatment that correct the error at the

root. However,

no single group can tackling 7,000

diseases. This is a global mission.

We design and test one medicine in one

country,

trial cross nations, share data

worldwide.

We overcome

scientific challenging,

regulatory barriers,

finance hardship.

We leverage global resources,

cutting edge technology like AI to

accelerate this,

turning a search from years to months

into days.

our most crucial partner, the patient

and the family.

They're the heroes

sharing their personal story and the

data advocating for research and the

resources. Most importantly as true

trailblazer

participant in clinical trial to test

the safety and the efficacy of the

medicine experimental medicine before it

become available to others. Their true

architect co-architect of their solution

consider the most recent proof of what's

possible

at Children Hospital of Philadelphia.

A baby named KJ was born with a severe

rare disease.

His body cannot process a protein due to

a single error on his DNA.

He spent the first few months in the

hospital on extremely limited diet.

Then at just six months later, he become

the first child to receive a customized

gene editing therapy that fix that

single error on his DNA designed for

only him.

The medicine was not made by a single

person or single group.

It takes collective effort from

biologist,

doctors,

regulators,

drug developers,

and the family who refused to wait.

All working together cross discipline in

record time.

The treatment worked. Today, KJ is not

only alive,

he's living and growing, thriving

in a life his family never thought

possible.

This is a medicine for one person, one

era, and one cure.

Kudos to those who have worked so hard

to make this possible.

And now the regulatory agency has opened

a new path to make those personalized

treatment possible.

All because our community has show all

are possible when we work together.

What emerges when pieces connect? The

hope

revolutionize all medicine. The

experience we learned from ultra rare

disease namely N equal to one

for example for KJ personalized

treatment for more common ones

the collaborative model

become a blueprint for solving global

puzzle.

See rare

not as footprint

but as 350

million teachers showing us the limit of

our of our system and the bonelessness

of human resilience.

When we work together we build a world

that solve the puzzles. We build a world

that understand the fundamental truth

in health,

in humanity, everyone counts.

Most recently, I have heard the student

I mentioned at the beginning of my talk,

the one who dropped her from university

is now planning her return to to the

university overseas after receiving a

vision restoration gene therapy.

She's able to read the textbook again.

For her, a new life has been restored.

This is why we work

to accelerate this hope

and make it available for millions

waiting.

Because here's a common sense that go

far beyond the medicine.

Every single one of us has felt like a

puzzle piece that doesn't quite fit.

Whether from a hidden struggle

or m misunderstood differences or a

moment when the world moved too fast and

left us behind.

The 350 million people affected by rare

disease are not a separate category.

They're a mirror. Their fight

for a diagnosis

reflects our own long to be seen. Their

wait

for treatment echoes every time we have

prayed for a second chance in our life.

Solving this puzzle is not just an act

of medicine. It's a declaration that

no person should be considered too few

to matter, too different to help

or too small to count.

This is a scene that bind us all in the

world of billions.

Every single story

is a piece of the same human puzzle.

We cannot do this alone.

Amplify

the possibility and the promise from n =

1

to n = to 350 million and hopefully to

everyone.

It will take

yes all of us.

Key Vocabulary

Vocabulary	Meanings
scientist /ˈsaɪəntɪst/ B2	noun - A person who is studying or has expert knowledge of one or more of the natural or physical sciences.
therapy /ˈθɛrəpi/ B2	noun - Treatment intended to relieve or heal a disorder.
blindness /ˈblaɪndnəs/ B1	noun - The state or condition of being unable to see.
navigate /ˈnævɪɡeɪt/ B2	verb - To find one's way over or through an area.
potential /pəˈtɛnʃəl/ B2	noun - Latent qualities or abilities that may be developed.
diagnostic /ˌdaɪəɡˈnɒstɪk/ C1	adjective - Concerned with the identification of the nature of an illness.
devastating /ˈdɛvəsteɪtɪŋ/ B2	adjective - Highly destructive or damaging.
intervention /ˌɪntəˈvɛnʃən/ C1	noun - The action of becoming involved in order to improve a situation.
agony /ˈæɡəni/ C1	noun - Extreme physical or mental suffering.
regulatory /ˈrɛɡjʊlətəri/ C1	adjective - Serving or intended to regulate something.
accelerate /əkˈsɛləreɪt/ B2	verb - To begin to move more quickly.
advocating /ˈædvəkeɪtɪŋ/ C1	verb - Publicly recommend or support.
trailblazer /ˈtreɪlˌbleɪzər/ C2	noun - A person who makes a new track through wild country; a pioneer.
efficacy /ˈɛfɪkəsi/ C2	noun - The ability to produce a desired or intended result.
thriving /ˈθraɪvɪŋ/ B2	adjective - Prosperous and growing; flourishing.

Key Grammar Structures

• A typo in the human genetic code that could cause life-threatening diseases such as blindness.

  ➔ Relative clause (defining)

  ➔ The clause 'that could cause...' modifies the noun 'typo', providing essential information.

• She lost the ability to navigate campus and had to leave from university.

  ➔ Modal verb of obligation (past form)

  ➔ 'Had to' is used here to indicate an external obligation in the past.

• Medicine calls her condition rare because it affects fewer than one in 2,000 people.

  ➔ Subordinating conjunction of reason

  ➔ 'Because' introduces the reason for calling the condition 'rare'.

• Not everyone can receive a genetic test that tells you what's wrong on the DNA.

  ➔ Noun clause (as object)

  ➔ 'What's wrong on the DNA' functions as the object of the verb 'tells'.

• It takes 10 to 15 years to develop one medicine.

  ➔ Cleft sentence structure (It + takes + time + to)

  ➔ 'It' is a dummy subject used here to express the duration of a process.

• This is not just a challenge; it's a human emergency hiding in plain sight.

  ➔ Participial phrase

  ➔ 'Hiding' (present participle) modifies 'emergency', indicating its state.

• The baby became the first child to receive a customized gene editing therapy.

  ➔ Infinitive as post-modifier

  ➔ 'To receive' modifies 'first child', specifying the action.

• When we work together, we build a world that solves the puzzles.

  ➔ First conditional (real present/future condition)

  ➔ The 'When' clause sets the condition for the main action.