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Are you sleeping restlessly, 00:06
feeling irritable or moody, 00:08
forgetting little things, 00:10
and feeling overwhelmed and isolated? 00:11
Don't worry. We've all been there. 00:14
You're probably just stressed out. 00:16
Stress isn't always a bad thing. 00:18
It can be handy for a burst of extra energy and focus, 00:20
like when you're playing a competitive sport, 00:24
or have to speak in public. 00:26
But when its continuous, 00:28
the kind most of us face day in and day out, 00:30
it actually begins to change your brain. 00:33
Chronic stress, 00:36
like being overworked or having arguments at home, 00:38
can affect brain size, 00:41
its structure, 00:42
and how it functions, 00:43
right down to the level of your genes. 00:45
Stress begins with something called 00:48
the hypothalamus pituitary adrenal axis, 00:49
a series of interactions 00:53
between endocrine glands in the brain and on the kidney, 00:55
which controls your body's reaction to stress. 00:59
When your brain detects a stressful situation, 01:02
your HPA axis is instantly activated 01:04
and releases a hormone called cortisol, which primes your body for instant action. 01:08
But high levels of cortisol over long periods of time 01:15
wreak havoc on your brain. 01:18
For example, chronic stress increases the activity level 01:20
and number of neural connections in the amygdala, 01:24
your brain's fear center. 01:28
And as levels of cortisol rise, 01:30
electric signals in your hippocampus, 01:32
the part of the brain associated with learning, memories, and stress control, 01:34
deteriorate. 01:39
The hippocampus also inhibits the activity of the HPA axis, 01:41
so when it weakens, 01:45
so does your ability to control your stress. 01:46
That's not all, though. 01:49
Cortisol can literally cause your brain to shrink in size. 01:51
Too much of it results in the loss of synaptic connections between neurons 01:55
and the shrinking of your prefrontal cortex, 02:00
the part of your brain the regulates behaviors like concentration, 02:03
decision-making, 02:06
judgement, 02:08
and social interaction. 02:09
It also leads to fewer new brain cells being made in the hippocampus. 02:11
This means chronic stress might make it harder for you to learn 02:16
and remember things, 02:19
and also set the stage for more serious mental problems, 02:21
like depression and eventually Alzheimer's disease. 02:24
The effects of stress may filter right down to your brain's DNA. 02:28
An experiment showed 02:33
that the amount of nurturing a mother rat provides its newborn baby 02:34
plays a part in determining how that baby responds to stress later in life. 02:38
The pups of nurturing moms turned out less sensitive to stress 02:43
because their brains developed more cortisol receptors, 02:48
which stick to cortisol and dampen the stress response. 02:51
The pups of negligent moms had the opposite outcome, 02:54
and so became more sensitive to stress throughout life. 02:58
These are considered epigenetic changes, 03:01
meaning that they effect which genes are expressed 03:04
without directly changing the genetic code. 03:07
And these changes can be reversed if the moms are swapped. 03:10
But there's a surprising result. 03:14
The epigenetic changes caused by one single mother rat 03:16
were passed down to many generations of rats after her. 03:19
In other words, the results of these actions were inheritable. 03:23
It's not all bad news, though. 03:28
There are many ways to reverse what cortisol does to your stressed brain. 03:30
The most powerful weapons are exercise and meditation, 03:34
which involves breathing deeply 03:38
and being aware and focused on your surroundings. 03:40
Both of these activities decrease your stress 03:43
and increase the size of the hippocampus, 03:46
thereby improving your memory. 03:49
So don't feel defeated by the pressures of daily life. 03:51
Get in control of your stress before it takes control of you. 03:54

– English Lyrics

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Lyrics & Translation

[English]
Are you sleeping restlessly,
feeling irritable or moody,
forgetting little things,
and feeling overwhelmed and isolated?
Don't worry. We've all been there.
You're probably just stressed out.
Stress isn't always a bad thing.
It can be handy for a burst of extra energy and focus,
like when you're playing a competitive sport,
or have to speak in public.
But when its continuous,
the kind most of us face day in and day out,
it actually begins to change your brain.
Chronic stress,
like being overworked or having arguments at home,
can affect brain size,
its structure,
and how it functions,
right down to the level of your genes.
Stress begins with something called
the hypothalamus pituitary adrenal axis,
a series of interactions
between endocrine glands in the brain and on the kidney,
which controls your body's reaction to stress.
When your brain detects a stressful situation,
your HPA axis is instantly activated
and releases a hormone called cortisol, which primes your body for instant action.
But high levels of cortisol over long periods of time
wreak havoc on your brain.
For example, chronic stress increases the activity level
and number of neural connections in the amygdala,
your brain's fear center.
And as levels of cortisol rise,
electric signals in your hippocampus,
the part of the brain associated with learning, memories, and stress control,
deteriorate.
The hippocampus also inhibits the activity of the HPA axis,
so when it weakens,
so does your ability to control your stress.
That's not all, though.
Cortisol can literally cause your brain to shrink in size.
Too much of it results in the loss of synaptic connections between neurons
and the shrinking of your prefrontal cortex,
the part of your brain the regulates behaviors like concentration,
decision-making,
judgement,
and social interaction.
It also leads to fewer new brain cells being made in the hippocampus.
This means chronic stress might make it harder for you to learn
and remember things,
and also set the stage for more serious mental problems,
like depression and eventually Alzheimer's disease.
The effects of stress may filter right down to your brain's DNA.
An experiment showed
that the amount of nurturing a mother rat provides its newborn baby
plays a part in determining how that baby responds to stress later in life.
The pups of nurturing moms turned out less sensitive to stress
because their brains developed more cortisol receptors,
which stick to cortisol and dampen the stress response.
The pups of negligent moms had the opposite outcome,
and so became more sensitive to stress throughout life.
These are considered epigenetic changes,
meaning that they effect which genes are expressed
without directly changing the genetic code.
And these changes can be reversed if the moms are swapped.
But there's a surprising result.
The epigenetic changes caused by one single mother rat
were passed down to many generations of rats after her.
In other words, the results of these actions were inheritable.
It's not all bad news, though.
There are many ways to reverse what cortisol does to your stressed brain.
The most powerful weapons are exercise and meditation,
which involves breathing deeply
and being aware and focused on your surroundings.
Both of these activities decrease your stress
and increase the size of the hippocampus,
thereby improving your memory.
So don't feel defeated by the pressures of daily life.
Get in control of your stress before it takes control of you.

Key Vocabulary

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Vocabulary Meanings

restlessly

/ˈrestləsli/

B2
  • adverb
  • - in a way that shows you cannot relax or stay still

irritable

/ˈɪrɪtəbl/

B1
  • adjective
  • - easily annoyed or angered

overwhelmed

/ˌoʊvərˈwelmd/

B2
  • adjective
  • - feeling unable to cope with something

isolated

/ˈaɪsəleɪtɪd/

B1
  • adjective
  • - feeling alone and without friends

stressed

/ˈstrest/

A2
  • adjective
  • - feeling worried or anxious

continuous

/kənˈtɪnjuəs/

B1
  • adjective
  • - never stopping

chronic

/ˈkrɑnɪk/

B2
  • adjective
  • - lasting for a long time

functions

/ˈfʌŋkʃənz/

B1
  • verb
  • - to work or operate in a proper or particular way

detects

/dɪˈtekt/

B1
  • verb
  • - to discover or identify the presence or existence of something

hormone

/ˈhɔrmoʊn/

B2
  • noun
  • - a chemical substance produced in the body that controls various functions

releases

/rɪˈliːsɪz/

A2
  • verb
  • - to let something go

deteriorate

/dɪˈtɪriərət/

B2
  • verb
  • - to become worse

inhibits

/ɪnˈhɪbɪts/

B2
  • verb
  • - to hinder or restrain

shrink

/ʃrɪŋk/

A2
  • verb
  • - to become smaller

concentration

/ˌkɑnsənˈtreɪʃən/

B1
  • noun
  • - the ability to focus on something

decision-making

/dɪˈsɪʒən ˌmeɪkɪŋ/

B2
  • noun
  • - the process of making choices

judgement

/ˈdʒʌdʒmənt/

B2
  • noun
  • - the ability to make considered decisions or come to sensible conclusions

nurturing

/ˈnɜrtʃərɪŋ/

B2
  • adjective
  • - showing care and attention

receptors

/rɪˈseptərz/

C1
  • noun
  • - a protein molecule that receives and responds to chemical signals

dampen

/ˈdæmpən/

B1
  • verb
  • - to reduce the force or intensity of

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