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In 1965, 17-year-old high school student, Randy Gardner 00:07
stayed awake for 264 hours. 00:12
That's 11 days to see how he'd cope without sleep. 00:16
On the second day, his eyes stopped focusing. 00:20
Next, he lost the ability to identify objects by touch. 00:23
By day three, Gardner was moody and uncoordinated. 00:27
At the end of the experiment, he was struggling to concentrate, 00:30
had trouble with short-term memory, 00:33
became paranoid, 00:35
and started hallucinating. 00:37
Although Gardner recovered without long-term psychological 00:39
or physical damage, 00:41
for others, losing shuteye can result in hormonal imbalance, 00:43
illness, 00:47
and, in extreme cases, death. 00:48
We're only beginning to understand why we sleep to begin with, 00:50
but we do know it's essential. 00:55
Adults need seven to eight hours of sleep a night, 00:56
and adolescents need about ten. 00:59
We grow sleepy due to signals from our body 01:02
telling our brain we are tired, 01:04
and signals from the environment telling us it's dark outside. 01:06
The rise in sleep-inducing chemicals, 01:10
like adenosine and melatonin, 01:12
send us into a light doze that grows deeper, 01:15
making our breathing and heart rate slow down 01:18
and our muscles relax. 01:20
This non-REM sleep is when DNA is repaired 01:23
and our bodies replenish themselves for the day ahead. 01:27
In the United States, 01:30
it's estimated that 30% of adults and 66% of adolescents 01:32
are regularly sleep-deprived. 01:36
This isn't just a minor inconvenience. 01:39
Staying awake can cause serious bodily harm. 01:41
When we lose sleep, 01:44
learning, 01:46
memory, 01:47
mood, 01:47
and reaction time are affected. 01:48
Sleeplessness may also cause inflammation, 01:50
halluciations, 01:53
high blood pressure, 01:54
and it's even been linked to diabetes and obesity. 01:55
In 2014, a devoted soccer fan died 02:00
after staying awake for 48 hours to watch the World Cup. 02:03
While his untimely death was due to a stroke, 02:08
studies show that chronically sleeping fewer than six hours a night 02:10
increases stroke risk by four and half times 02:14
compared to those getting a consistent seven to eight hours of shuteye. 02:18
For a handful of people on the planet who carry a rare inherited genetic mutation, 02:22
sleeplessness is a daily reality. 02:27
This condition, known as Fatal Familial Insomnia, 02:30
places the body in a nightmarish state of wakefulness, 02:34
forbidding it from entering the sanctuary of sleep. 02:37
Within months or years, 02:40
this progressively worsening condition leads to dementia and death. 02:42
How can sleep deprivation cause such immense suffering? 02:47
Scientists think the answer lies with the accumulation of waste prducts 02:51
in the brain. 02:55
During our waking hours, 02:56
our cells are busy using up our day's energy sources, 02:58
which get broken down into various byproducts, 03:01
including adenosine. 03:04
As adenosine builds up, 03:06
it increases the urge to sleep, also known as sleep pressure. 03:08
In fact, caffeine works by blocking adenosine's receptor pathways. 03:12
Other waste products also build up in the brain, 03:18
and if they're not cleared away, they collectively overload the brain 03:20
and are thought to lead to the many negative symptoms of sleep deprivation. 03:24
So, what's happening in our brain when we sleep to prevent this? 03:29
Scientists found something called the glymphatic system, 03:33
a clean-up mechanism that removes this buildup 03:37
and is much more active when we're asleep. 03:40
It works by using cerebrospinal fluid to flush away toxic byproducts 03:43
that accumulate between cells. 03:48
Lymphatic vessels, which serve as pathways for immune cells, 03:50
have recently been discovered in the brain, 03:54
and they may also play a role in clearing out the brain's daily waste products. 03:57
While scientists continue exploring the restorative mechanisms behind sleep, 04:03
we can be sure that slipping into slumber is a necessity 04:08
if we want to maintain our health and our sanity. 04:13

– English Lyrics

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Lyrics & Translation

[English]
In 1965, 17-year-old high school student, Randy Gardner
stayed awake for 264 hours.
That's 11 days to see how he'd cope without sleep.
On the second day, his eyes stopped focusing.
Next, he lost the ability to identify objects by touch.
By day three, Gardner was moody and uncoordinated.
At the end of the experiment, he was struggling to concentrate,
had trouble with short-term memory,
became paranoid,
and started hallucinating.
Although Gardner recovered without long-term psychological
or physical damage,
for others, losing shuteye can result in hormonal imbalance,
illness,
and, in extreme cases, death.
We're only beginning to understand why we sleep to begin with,
but we do know it's essential.
Adults need seven to eight hours of sleep a night,
and adolescents need about ten.
We grow sleepy due to signals from our body
telling our brain we are tired,
and signals from the environment telling us it's dark outside.
The rise in sleep-inducing chemicals,
like adenosine and melatonin,
send us into a light doze that grows deeper,
making our breathing and heart rate slow down
and our muscles relax.
This non-REM sleep is when DNA is repaired
and our bodies replenish themselves for the day ahead.
In the United States,
it's estimated that 30% of adults and 66% of adolescents
are regularly sleep-deprived.
This isn't just a minor inconvenience.
Staying awake can cause serious bodily harm.
When we lose sleep,
learning,
memory,
mood,
and reaction time are affected.
Sleeplessness may also cause inflammation,
halluciations,
high blood pressure,
and it's even been linked to diabetes and obesity.
In 2014, a devoted soccer fan died
after staying awake for 48 hours to watch the World Cup.
While his untimely death was due to a stroke,
studies show that chronically sleeping fewer than six hours a night
increases stroke risk by four and half times
compared to those getting a consistent seven to eight hours of shuteye.
For a handful of people on the planet who carry a rare inherited genetic mutation,
sleeplessness is a daily reality.
This condition, known as Fatal Familial Insomnia,
places the body in a nightmarish state of wakefulness,
forbidding it from entering the sanctuary of sleep.
Within months or years,
this progressively worsening condition leads to dementia and death.
How can sleep deprivation cause such immense suffering?
Scientists think the answer lies with the accumulation of waste prducts
in the brain.
During our waking hours,
our cells are busy using up our day's energy sources,
which get broken down into various byproducts,
including adenosine.
As adenosine builds up,
it increases the urge to sleep, also known as sleep pressure.
In fact, caffeine works by blocking adenosine's receptor pathways.
Other waste products also build up in the brain,
and if they're not cleared away, they collectively overload the brain
and are thought to lead to the many negative symptoms of sleep deprivation.
So, what's happening in our brain when we sleep to prevent this?
Scientists found something called the glymphatic system,
a clean-up mechanism that removes this buildup
and is much more active when we're asleep.
It works by using cerebrospinal fluid to flush away toxic byproducts
that accumulate between cells.
Lymphatic vessels, which serve as pathways for immune cells,
have recently been discovered in the brain,
and they may also play a role in clearing out the brain's daily waste products.
While scientists continue exploring the restorative mechanisms behind sleep,
we can be sure that slipping into slumber is a necessity
if we want to maintain our health and our sanity.

Key Vocabulary

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Vocabulary Meanings

sleep

/sliːp/

A1
  • noun
  • - the natural periodic suspension of consciousness and bodily functions
  • verb
  • - to rest in a state of natural unconsciousness

awake

/əˈweɪk/

A2
  • verb
  • - to stop sleeping; to become conscious
  • adjective
  • - not sleeping; alert

deprivation

/ˌdɛprɪˈveɪʃən/

C1
  • noun
  • - the lack of basic necessities, especially sleep

memory

/ˈmɛməri/

B1
  • noun
  • - the faculty by which the mind stores and remembers information

paranoid

/ˈperəˌnɔɪd/

C1
  • adjective
  • - characterized by extreme and irrational distrust of others

hallucinating

/həˈluːsɪˌneɪtɪŋ/

C1
  • verb
  • - to experience a perception of something that isn’t actually present

adenosine

/əˈdɛnəsɪn/

C2
  • noun
  • - a nucleoside that builds up in the brain and promotes sleep pressure

melatonin

/ˈmɛləˌtoʊnɪn/

C2
  • noun
  • - a hormone that regulates sleep–wake cycles

glymphatic

/ɡlaɪmˈfætɪk/

C2
  • adjective
  • - relating to the brain’s waste‑clearance system that uses glial cells and lymphatic pathways

cerebrospinal

/ˌsɛrəbrəˈspaɪnəl/

C2
  • adjective
  • - pertaining to the fluid that surrounds the brain and spinal cord

inflammation

/ˌɪnfləˈmeɪʃən/

C1
  • noun
  • - a localized physical condition in which part of the body becomes reddened, swollen, hot, and painful

stroke

/stroʊk/

B2
  • noun
  • - a sudden interruption of the blood supply to the brain, causing tissue damage

insomnia

/ɪnˈsɒmniə/

B2
  • noun
  • - the chronic inability to fall or stay asleep

fatal

/ˈfeɪtəl/

B2
  • adjective
  • - causing death; deadly

hormonal

/hɔrˈmoʊnəl/

B2
  • adjective
  • - relating to hormones or their activity

imbalance

/ˌɪmbəˈlæns/

C1
  • noun
  • - a condition in which something is out of proportion or equilibrium

replenish

/rɪˈplɛnɪʃ/

C1
  • verb
  • - to fill again; restore to a former level

pressure

/ˈprɛʃər/

B1
  • noun
  • - the force exerted on a surface or the feeling of urgency or demand

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